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dc.rights.licensehttps://creativecommons.org/licenses/by/4.0/es_AR
dc.contributor.authorSedeño, Lucases_AR
dc.contributor.authorCouto, Blases_AR
dc.contributor.authorMelloni, Margheritaes_AR
dc.contributor.authorCanales-Johnson, Andréses_AR
dc.contributor.authorYoris, Adrianes_AR
dc.contributor.authorBaez, Sandraes_AR
dc.contributor.authorEsteves, Soles_AR
dc.contributor.authorVelasquez, Marcelaes_AR
dc.contributor.authorBarttfeld, Pabloes_AR
dc.contributor.authorSigman, Marianoes_AR
dc.contributor.authorKichic, Rafaeles_AR
dc.contributor.authorChialvo, Dantees_AR
dc.contributor.authorManes, Facundoes_AR
dc.contributor.authorBekinschtein, Tristan A.es_AR
dc.contributor.authorIbáñez, Agustínes_AR
dc.date.accessioned2018-08-06T14:31:55Z
dc.date.available2018-08-06T14:31:55Z
dc.date.issued2014-06-26
dc.identifierdoi: https://doi.org/10.1371/journal.pone.0098769es_AR
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0098769es_AR
dc.identifier.urihttps://repositorio.utdt.edu/handle/20.500.13098/11076
dc.description.abstractDepersonalization-Derealization Disorder (DD) typically manifests as a disruption of body self-awareness. Interoception 2 defined as the cognitive processing of body signals2 has been extensively considered as a key processing for body selfawareness. In consequence, the purpose of this study was to investigate whether there are systematic differences in interoception between a patient with DD and controls that might explain the disembodiment symptoms suffered in this disease. To assess interoception, we utilized a heartbeat detection task and measures of functional connectivity derived from fMRI networks in interoceptive/exteroceptivo/mind-wandering states. Additionally, we evaluated empathic abilities to test the association between interoception and emotional experience. The results showed patient’s impaired performance in the heartbeat detection task when compared to controls. Furthermore, regarding functional connectivity, we found a lower global brain connectivity of the patient relative to controls only in the interoceptive state. He also presented a particular pattern of impairments in affective empathy. To our knowledge, this is the first experimental research that assesses the relationship between interoception and DD combining behavioral and neurobiological measures. Our results suggest that altered neural mechanisms and cognitive processes regarding body signaling might be engaged in DD phenomenology. Moreover, our study contributes experimental data to the comprehension of brain-body interactions and the emergence of self-awareness and emotional feelings.es_AR
dc.format.extent17 p.es_AR
dc.format.mediumapplication/pdfes_AR
dc.languageenges_AR
dc.relation.ispartofPLoS ONE 9(6), (2016). ISSN: 1932-6203es_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.subjectEmociones
dc.subjectCognición
dc.subjectImagen por resonancia magnética
dc.subjectPruebas neuropsicológicas
dc.subjectAtención
dc.subjectTrastornos de ansiedad
dc.titleHow do you feel when you can’t feel your body? Interoception, functional connectivity and emotional processing in depersonalization-derealization disorderes_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.subject.keywordEmotionses_AR
dc.subject.keywordCognitiones_AR
dc.subject.keywordFunctional magnetic resonance imaginges_AR
dc.subject.keywordNeurophsychological testinges_AR
dc.subject.keywordNatural networkses_AR
dc.subject.keywordGraph theoryes_AR
dc.subject.keywordAttentiones_AR
dc.subject.keywordAnxietyes_AR
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_AR
dc.description.filiationFil: Sedeño, Lucas. Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile. National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Couto, Blas. Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile. National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Melloni, Margherita. Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile. National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Canales-Johnson, Andrés. UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile. Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdomes_AR
dc.description.filiationFil: Yoris, Adrian. Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Baez, Sandra. Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile. National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Esteves, Sol. Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Velasquez, Marcela. Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Barttfeld, Pablo. Physics Department, Laboratory of Integrative Neuroscience, FCEyN UBA and IFIBA, Buenos Aires, Argentina. Cognitive Neuroimaging Unit, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, Francees_AR
dc.description.filiationFil: Sigman, Mariano. Physics Department, Laboratory of Integrative Neuroscience, FCEyN UBA and IFIBA, Buenos Aires, Argentina. National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina. Universidad Torcuato Di Tella, Escuela de Negocios, Laboratorio de Neurociencia, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Kichic, Rafael. Anxiety Clinic, INECO (Institute of Cognitive Neurology), Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Chialvo, Dante. National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina. Departamento de Matema´ticas y Ciencias, Universidad de San Andre´ s, Buenos Aires, Argentina. David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of Americaes_AR
dc.description.filiationFil: Manes, Facundo. Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile. National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina. Australian Research Council (ACR) Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, New South Wales, Australiaes_AR
dc.description.filiationFil: Bekinschtein, Tristan A. Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdomes_AR
dc.description.filiationFil: Ibáñez, Agustín. Laboratory of Experimental Psychology and Neuroscience (LPEN), INECO (Institute of Cognitive Neurology) and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile. Universidad Auto´noma del Caribe, Barranquilla, Colombia. Australian Research Council (ACR) Centre of Excellence in Cognition and its Disorders, Macquarie University, Sydney, New South Wales, Australiaes_AR


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