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dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/es_AR
dc.contributor.authorIbañez, Agustínes_AR
dc.contributor.authorCetkovich, Marceloes_AR
dc.contributor.authorPetroni, Agustínes_AR
dc.contributor.authorUrquina, Hugoes_AR
dc.contributor.authorBaez, Sandraes_AR
dc.contributor.authorGonzalez-Gadea, María Luzes_AR
dc.contributor.authorKamienkowski, Juan Estebanes_AR
dc.contributor.authorTorralva, Teresaes_AR
dc.contributor.authorTorrente, Fernandoes_AR
dc.contributor.authorStrejilevich, Sergioes_AR
dc.contributor.authorTeitelbaum, Juliaes_AR
dc.contributor.authorHurtado, Estebanes_AR
dc.contributor.authorGuex, Raphaeles_AR
dc.contributor.authorMelloni, Margheritaes_AR
dc.contributor.authorLischinsky, Aliciaes_AR
dc.contributor.authorSigman, Marianoes_AR
dc.contributor.authorManes, Facundoes_AR
dc.date.accessioned2018-08-15T13:21:34Z
dc.date.available2018-08-15T13:21:34Z
dc.date.issued2012-05-18
dc.identifierdoi: 10.1371/journal.pone.0037306es_AR
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0037306es_AR
dc.identifier.urihttps://repositorio.utdt.edu/handle/utdt/11082
dc.description.abstractBackground: Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) share DSM-IV criteria in adults and cause problems in decision-making. Nevertheless, no previous report has assessed a decision-making task that includes the examination of the neural correlates of reward and gambling in adults with ADHD and those with BD. Methodology/Principal Findings: We used the Iowa gambling task (IGT), a task of rational decision-making under risk (RDMUR) and a rapid-decision gambling task (RDGT) which elicits behavioral measures as well as event-related potentials (ERPs: fERN and P3) in connection to the motivational impact of events. We did not observe between-group differences for decision-making under risk or ambiguity (RDMUR and IGT); however, there were significant differences for the ERP-assessed RDGT. Compared to controls, the ADHD group showed a pattern of impaired learning by feedback (fERN) and insensitivity to reward magnitude (P3). This ERP pattern (fERN and P3) was associated with impulsivity, hyperactivity, executive function and working memory. Compared to controls, the BD group showed fERN- and P3-enhanced responses to reward magnitude regardless of valence. This ERP pattern (fERN and P3) was associated with mood and inhibitory control. Consistent with the ERP findings, an analysis of source location revealed reduced responses of the cingulate cortex to the valence and magnitude of rewards in patients with ADHD and BD. Conclusions/Significance: Our data suggest that neurophysiological (ERPs) paradigms such as the RDGT are well suited to assess subclinical decision-making processes in patients with ADHD and BD as well as for linking the cingulate cortex with action monitoring systems.es_AR
dc.format.extent11 p.es_AR
dc.format.mediumapplication/pdfes_AR
dc.languageenges_AR
dc.relation.ispartofPLoS ONE 7(5), (2012). ISSN: 1932-6203es_AR
dc.rightsinfo:eu-repo/semantics/openAccesses_AR
dc.subjectTrastorno por Déficit de Atención con Hiperactividades_AR
dc.subjectToma de decisioneses_AR
dc.subjectHelechoses_AR
dc.subjectPotenciales evocadoses_AR
dc.subjectPruebas neuropsicológicases_AR
dc.subjectTrastornos del conocimientoes_AR
dc.subjectConducta impulsivaes_AR
dc.subjectNeuropsicologíaes_AR
dc.titleThe neural basis of decision-making and reward processing in adults with euthymic bipolar disorder or attention-deficit/hyperactivity disorder (ADHD)es_AR
dc.typeinfo:eu-repo/semantics/articlees_AR
dc.subject.keywordADHDes_AR
dc.subject.keywordDecision makinges_AR
dc.subject.keywordFernses_AR
dc.subject.keywordEvent-related potentialses_AR
dc.subject.keywordNeurophsychological testinges_AR
dc.subject.keywordCognitive impairmentes_AR
dc.subject.keywordImpulsivityes_AR
dc.subject.keywordNeuropsychologyes_AR
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_AR
dc.description.filiationFil: Ibañez, Agustín. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. National Scientific and Technical Research Council, Buenos Aires, Argentina. Laboratory of Cognitive and Social Neuroscience, Universidad Diego Portales, Santiago, Chile,es_AR
dc.description.filiationFil: Cetkovich, Marcelo. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Petroni, Agustín.National Scientific and Technical Research Council, Buenos Aires, Argentina. Integrative Neuroscience Laboratory, Physics Department, University of Buenos Aireses_AR
dc.description.filiationFil: Urquina, Hugo. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. Neurored, Universidad Surcolombiana, Neiva, Colombiaes_AR
dc.description.filiationFil: Baez, Sandra. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. National Scientific and Technical Research Council, Buenos Aires, Argentina. Pontificia Universidad Cato´ lica Argentina, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Gonzalez-Gadea, María Luz. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina. National Scientific and Technical Research Council, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Kamienkowski, Juan Esteban. Integrative Neuroscience Laboratory, Physics Department, University of Buenos Aires, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Torralva, Teresa. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Torrente, Fernando. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Strejilevich, Sergio. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Teitelbaum, Julia. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Hurtado, Esteban. Laboratory of Cognitive and Social Neuroscience, Universidad Diego Portales, Santiago, Chile. Pontificia Universidad Católica de Chile, Santiago, Chilees_AR
dc.description.filiationFil: Guex, Raphael. Laboratory for Behavioral Neurology and Imaging of Cognition, University of Geneva, Geneva, Switzerlandes_AR
dc.description.filiationFil: Melloni, Margherita. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Lischinsky, Alicia. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Sigman, Mariano. National Scientific and Technical Research Council, Buenos Aires, Argentina. Universidad Torcuato Di Tella, Escuela de Negocios, Laboratorio de Neurociencia, Buenos Aires, Argentinaes_AR
dc.description.filiationFil: Manes, Facundo. Laboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology and Institute of Neuroscience, Favaloro University, Buenos Aires, Argentinaes_AR


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